TYPE: Compulsory module
CREDITS: 9 
COORDINATOR: Josep Quer Sivila, PhD - personal data

This module aims to approach the students to the functioning of research in a tertiary hospital, by showing the different medical states from diagnostic to care of diseases.

The aim of the module is to enable students to acquire the basic knowledge on the ethical, methodological, regulatory and logistical aspects used in translational and clinical research, to be able to plan experiments in human pathology based on Genomics, Proteomics, Cytomics and Metabolomics, to acquire the knowledge to identify the transferability of the results of their research to the market, and to understand the bases and the application of new diagnostic tools (massive sequencing, magnetic resonance imaging, microarrays, nanotechnology, etc.) and advanced therapies in human pathology.

CONTENTS

SECTION I: INTRODUCTION TO CLINICAL PRACTICE IN THE HOSPITAL ENVIRONMENT 

1. The Health System in Catalonia: function, structure and management of the Institut Català de la Salut (ICS).
2. Pathology of the major and minor syndromes
3. Diagnostic methodologies                       
4. Pharmacology and pharmacy
5. Surgery

SECTION II: CLINICAL RESEARCH AND CLINICAL TRIALS

1. Methodologies for Clinical Research
2. Clinical trials
3. Legal and ethical issues of clinical research
4. Observational epidemiologic studies: Design, advantages and disadvantages. Principal bias
5. Operational aspects. How to manage with clinical trials. Most frequent problems

SECTION III: PRECLINICAL RESEARCH

1. Introduction to Core Facilities High-Tech Equipments
2. Biobanks. Biomedical Research with human biological samples
3. Animal House Facility
4. UAT-UEB-USMIB. Omic technologies for personalized medicine
5. Overview: Use of genetically modified animal models

SECTION IV: TOOLS FOR DIAGNOSIS IN HUMAN PATHOLOGY

1. Massive sequencing past present and future
2. Cytogenetics. Prenatal diagnosis
3. GWAs & Microarrays
4. Proteomics. Organels

SECTION V: ADVANCED THERAPIES

1. Preclinical Evaluation of New Therapeutic Agents
2. Cell therapy
3. Nanotechnology

TEACHERS