Immune, Respiratory, Sistemic and Endocrine System Diseases
TYPE: Elective module
COORDINATOR: Josep Villena, PhD- personal profile
This module aims to show the principal respiratory, immune, systemic and endocrine system diseases and the molecular approaches used for understanding the pathophysiological processes underlying these diseases.
SECTION I: IMMUNE SYSTEM DISEASES
- Review of the immune response in health and disease. New and evolving concepts relevant to the immunopathology.
- Natural and Intrinsic immunity, main mechanisms and implications for disease.
- Thymus gland, maturation of T lymphocytes relationship to autoimmunity. The role of AIRE gene in tolerance and autoimmunity.
- Tumor immunology, classical and new approaches.
SECTION II: SYSTEMIC DISEASES
- Vasculitis. An overview on the immunologic basis depending on the different affected vessels.
- Systemic lupus erythematosus. A model of autoimmune disease.
- Amyloidosis, paraproteins and IgS subtypes. From the bench to the bed.
- Systemic sclerosis and myositis. Genetic background and autoantibodies subtypes
SECTION III: RESPIRATORY DISEASES
- New advances in the pathology of asthma and COPD
- Occupational and environmental respiratory diseases
- Laboratory techniques for research in respiratory diseases
- Environmental studies in respiratory research
- Laboratory techniques and environmental studies for research in respiratory diseases
- Non-invasive methods for studying pulmonary inflammation
- Animal models for research in respiratory diseases
SECTION IV: ENDOCRINE SYSTEM DISEASES
- Overview of endocrine related diseases: basic concepts and clinical features
- Diabetes and its complications: the clinical point of view
- Mechanisms of hormone action: membrane and nuclear receptors.
- Etiology of type 2 diabetes and insulin resistance: lipotoxicity
- Etiology of type 2 diabetes and insulin resistance: Inflammation & ER stress
- Mitochondrial function and metabolic disease
- Brown adipose tissue and energy homeostasis: a new therapeutic target.
- New therapeutic target against obesity. Introduction to sex hormone-binding globulin (SHBG) and sex steroids
- SHBG as a marker of metabolic disorders.
- In vitro and in vivo models to study SHBG role in the obesity development
- New functions of SHBG in human physiology
|Roger Colobran Oriol|
|Manuel Hernández González|
|Ricardo Pujol Borrell|
|María Jesús Cruz|
|Susana Gómez Ollés|
|Xavier Muñoz Gall|
|Marta Garcia Ramírez|
|David Martínez Selva|
|Josep Villena Delgado|