TYPE: Elective module
CREDITS: 6
COORDINATOR: Josep Villena, PhD- personal profile

This module aims to show the principal respiratory, immune, systemic and endocrine system diseases and the molecular approaches used for understanding the pathophysiological processes underlying these diseases.

CONTENT

SECTION  I:  IMMUNE SYSTEM DISEASES

  1. Review of the immune response in health and disease. New and evolving concepts relevant to the immunopathology.
  2. Natural and Intrinsic immunity, main mechanisms and implications for disease.
  3. Thymus gland, maturation of T lymphocytes relationship to autoimmunity. The role of AIRE gene in tolerance and autoimmunity.
  4. Tumor immunology, classical and new approaches.

SECTION II: SYSTEMIC DISEASES

  1. Vasculitis. An overview on the immunologic basis depending on the different affected vessels.
  2. Systemic lupus erythematosus. A model of autoimmune disease.
  3. Amyloidosis, paraproteins and IgS subtypes. From the bench to the bed.
  4. Systemic sclerosis and myositis. Genetic background and autoantibodies subtypes

SECTION III: RESPIRATORY DISEASES

  1. New advances in the pathology of asthma and COPD
  2. Occupational and environmental respiratory diseases
  3. Laboratory techniques for research in respiratory diseases
  4. Environmental studies in respiratory research
  5. Laboratory techniques and environmental studies for research in respiratory diseases
  6. Non-invasive methods for studying pulmonary inflammation
  7. Animal models for research in respiratory diseases

 SECTION IV: ENDOCRINE SYSTEM DISEASES

  1. Overview of endocrine related diseases: basic concepts and clinical features
  2. Diabetes and its complications: the clinical point of view
  3. Mechanisms of hormone action: membrane and nuclear receptors.
  4. Etiology of type 2 diabetes and insulin resistance: lipotoxicity
  5. Etiology of type 2 diabetes and insulin resistance: Inflammation & ER stress
  6. Mitochondrial function and metabolic disease
  7. Brown adipose tissue and energy homeostasis: a new therapeutic target.
  8. New therapeutic target against obesity. Introduction to sex hormone-binding globulin (SHBG) and sex steroids
  9. SHBG as a marker of metabolic disorders.
  10. In vitro and in vivo models to study SHBG role in the obesity development
  11. New functions of SHBG in human physiology 

TEACHERS

Isabel Caragol
Roger Colobran Oriol
Manuel Hernández González
Sara Marsal
Ricardo Pujol Borrell
María Jesús Cruz
Susana Gómez Ollés
Xavier Muñoz Gall
Andreea Ciudin
Marta Garcia Ramírez
David Martínez Selva
Josep Villena Delgado
Núria Camats